From Ligand bias to DREADDs-Engineered Mice: Dissecting the Pharmacology and Function of the Short Chain Fatty Receptor FFA2

Since the de-orphanization of the short chain fatty acid receptor FFA2 in 2003, the interest surrounding this receptor has dramatically risen in connection with its expression in tissues involved in metabolic disorders and the emerging evidence of a gut microbiota role in modulating this receptor. Despite this, a general paucity of selective ligands and the contrasting results obtained from FFA2 knockout animal models have provided an insufficient understanding of the pathophysiological role of this receptor. In this talk, Dr. Daniele Bolognini will present new pharmacological approaches that will help to better dissect the pharmacology and the physiological role of FFA2 receptor.