CIHR Project Grants - October 2016 Competition

CIHR Project Grants - October 2016 Competition

Allison Crawford

Centre for Addiction and Mental Health

Department of Psychiatry

Evaluating the impact of the Project ECHO model on primary care management of mental health and addictions

                                   573,750

John A. Cunningham

Centre for Addiction and Mental Health

Department of Psychiatry

Does providing a brief Internet intervention for hazardous alcohol use to people seeking online help for depression reduce both alcohol use and depression symptoms among participants with these dual disorders? Randomized controlled trial

                                   466,652

Margaret Hahn

Centre for Addiction and Mental Health

Department of Psychiatry

Unraveling the role of central insulin action in relation to glucose abnormalities in first-time antipsychotic users

                                   420,750

Jeffrey H. Meyer

Centre for Addiction and Mental Health

Department of Psychiatry

Positron Emission Tomography Imaging Monoamine Oxidase B in Major Depressive Disorder With and Without Comorbid Traumatic Brain Injury

                                   531,676

Sibille Etienne

Centre for Addiction and Mental Health

Department of Psychiatry

Molecular Rules in Brain Cell Microcircuits in Health and Disease

                                   742,050

Nicholas Reed

Holland Bloorview Kids Rehabilitation Hospital

Occupational Science & Occupational Therapy

Concussion & You: A peer-led approach to raising concussion awareness in Canadian high schools

                                   600,524

Gabrielle L. Boulianne

Hospital for Sick Children

Department of Molecular Genetics

Evaluating the Potential of ACE Inhibitors in Alzheimer's Disease

                                   562,275

Charles M. Deber

Hospital for Sick Children

Department of Biochemistry

Peptide-based Inhibitors of Bacterial Drug Efflux Pumps

                                   573,750

William Brent Derry

Hospital for Sick Children

Department of Molecular Genetics

Molecular and cellular mechanisms that govern the development of cerebral cavernous malformations (CCM)

                                   869,550

James Dowling

Hospital for Sick Children

Department of Paediatrics

Therapy development for myotubular myopathy and related disorders

                                   765,000

Yigal Dror

Hospital for Sick Children

Department of Paediatrics

Dissecting the hematopoietic hierarchy and function using inherited human disease models of hematopoietic stem cell/progenitor loss

                                   849,152

Yigal Dror

Hospital for Sick Children

Department of Paediatrics

Dissecting early and progressive leukemogenic impairments in the hematopoietic hierarchy and function using pre-leukemic inherited bone marrow failure syndromes as human disease models

                                1,005,975

Patricia Lynne Howell

Hospital for Sick Children

Department of Biochemistry

Biosynthesis and Export of Pseudomonas aeruginosa alginate

                                1,002,150

Xi Huang

Hospital for Sick Children

Department of Molecular Genetics

Establishing chloride intracellular channel CLIC1 as a therapeutic target for pediatric brain tumor

                                   677,025

Walter H. Kahr

Hospital for Sick Children

Department of Paediatrics

Role of NBEAL2 in blood platelet maturation

                                   661,725

Brian Patrick Kavanagh

Hospital for Sick Children

Department of Anesthesia

Acute Lung Injury - Directions from Therapeutic Hypercapnia

                                   688,500

Christoph Licht

Hospital for Sick Children

Department of Paediatrics

NETs in complement-mediated TMA

                                   650,252

Aleixo M. Muise

Hospital for Sick Children

Department of Paediatrics

Genetic and Functional Studies in VEOIBD

                                1,051,875

John Parkinson

Hospital for Sick Children

Department of Paediatrics

Identifying new therapeutic opportunities by elucidating the physical protein complexes and pathways driving invasion in malaria parasites

                                   948,600

Steven Prescott

Hospital for Sick Children

Department of Physiology

Chloride dysregulation and neuropathic pain: Linking molecular mechanisms with altered pain processing via identification of cellular and circuit level changes

                                   876,615

Steven Prescott

Hospital for Sick Children

Department of Physiology

Probing the spike initiation properties of primary somatosensory neurons using optogenetics

                                   845,324

James T. Rutka

Hospital for Sick Children

Department of Surgery

Molecular Therapeutic Targeting of Malignant Gliomas

                                   914,175

Giles E. Santyr

Hospital for Sick Children

Department of Medical Biophysics

Structural and Functional MRI Assessment of Treatment Response in Early Cystic Fibrosis Lung Disease

                                   619,650

Giles E. Santyr

Hospital for Sick Children

Department of Medical Biophysics

Structural and Functional MRI in Preclinical Models of Bronchopulmonary Dysplasia

                                   485,775

John G. Sled

Hospital for Sick Children

Department of Medical Biophysics

Imaging of cerebral vascular adaptation following traumatic brain injury

                                   910,350

John G. Sled

Hospital for Sick Children

Department of Medical Biophysics

Ultrasound detection of placental pathology based on hemodynamic pulse wave reflection

                                   799,425

Sean B. Rourke

Ontario HIV Treatment Network

Department of Psychiatry

The Ontario Integrated Supervised Injection Services Research Program: Examining Uptake and Impacts in Different Community Settings and Models of Care

                                   646,424

Rod A. Bremner

Sinai Health System

Department of Ophthalmology and Vision Sciences

Opposite roles of MYCN and YAP in cancer initiation

                                   726,750

Caroline K. Kramer

Sinai Health System

Department of Medicine

Empagliflozin and the Preservation of Pancreatic Beta-Cell Function in Women with Recent Gestational Diabetes

                                   416,924

Mei Zhen

Sinai Health System

Department of Molecular Genetics

An Anatomic and Genetic Dissection of Synapse Formation and Synapse Remodelling

                                   719,100

Andrew Advani

St. Michael's Hospital

Department of Medicine

Non-coding RNA in diabetic kidney disease

                                   650,250

Kim A. Connelly

St. Michael's Hospital

Department of Medicine

Elucidating the role of alpha 11 integrin in mediating cardiac fibroblast-extracellular matrix interactions in health and disease

                                   474,300

Paul Dorian

St. Michael's Hospital

Department of Medicine

The Epinephrine Randomized Optimal Versus Current Dose (EpiROC) Canada Trial

                                2,509,200

Krishna K. Singh

St. Michael's Hospital

Department of Surgery

The Emerging Field of Cardiovascular-Oncology: Role of Tumor Suppressor Breast Cancer Susceptibility Gene 2 (BRCA2) in Endothelial Dysfunction and Atherosclerosis

                                   229,500

Subodh S. Verma

St. Michael's Hospital

Department of Surgery

BRCA1 therapy for heart failure

                                   765,000

Vladimir Vuksan

St. Michael's Hospital

Department of Nutritional Sciences

The Role of Dietary Nitrate on Blood Pressure and Cardiovascular Disease Risk Factors: A Randomized, Controlled Trial in Individuals With Elevated Blood pPressure

                                   325,124

Darren A. Yuen

St. Michael's Hospital

Department of Medicine

Sweet and Stiff: How diabetes activates YAP and TAZ to trigger kidney fibrosis

                                   895,050

Michele K. Anderson

Sunnybrook Health Sciences Centre

Department of Immunology

Transcriptional regulation of gamma delta T-cell development and functional diversification

                                   860,625

Elizabeth V. Asztalos

Sunnybrook Health Sciences Centre

Department of Paediatrics

Does bovine lactoferrin (bLF) improve morbidity-free survival and severe retinopathy in very low birthweight infants? The Lactoferrin Infant Feeding Trial (LIFT).

                                1,185,750

Clare L. Atzema

Sunnybrook Health Sciences Centre

Department of Medicine

Atrial Fibrillation in the Emergency Room (The AFTER Study): Prospective validation of the clinical decision instruments

                                   348,074

Charles Cunningham

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

Hyperpolarzied 13C MRI for the Management of Heart Failure

                                   726,752

Nick Daneman

Sunnybrook Health Sciences Centre

Department of Medicine

Feedback to Improve Rational STrategies of Antibiotic Initiation and Duration in Long Term Care (FIRST AID - LTC)

                                   489,601

Dennis Ko

Sunnybrook Health Sciences Centre

Department of Medicine

Assessing and Improving the Quality of Care and Outcomes of Patients with Atrial Fibrillation in Canada

                                   517,141

Krista L. Lanctot

Sunnybrook Health Sciences Centre

Department of Pharmacology & Toxicology

Efficacy and Safety of N-acetylcysteine (NAC) in patients with mild vascular cognitive impairment

                                   673,200

JoAnne McLaurin

Sunnybrook Health Sciences Centre

Department of Laboratory Medicine & Pathobiology

Contribution of Mid-life Comorbidities to Alzheimer's Disease

                                1,002,150

Mihaela Pop

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

Personalized MRI-based predictive models to guide VT therapy

                                   378,675

David E. Spaner

Sunnybrook Health Sciences Centre

Department of Medicine

Targeting Interferon-beta in leukemia immunotherapy

                                   459,000

Burton B. Yang

Sunnybrook Health Sciences Centre

Department of Laboratory Medicine & Pathobiology

The role of circ-Dnmt1 in cardiac remodeling and senescence

                                   695,770

Laurie E. Ailles

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Functional and Molecular Characterization of Cancer-Associated Fibroblasts in High Grade Serous Ovarian Cancer

                                   698,445

Nora K. Cullen

UHN - Toronto Rehabilitation Institute

Department of Medicine

A population based perspective of hypoxic ischemic brain injury in Ontario, Canada

                                   141,526

Marcelo Cypel

UHN - Toronto General Hospital

Department of Surgery

Lung Transplantation using Hepatitis C Positive Donors to Hepatitis C Negative Recipients: A Safety Trial

                                   612,000

Ralph S. DaCosta

UHN - Princess Margaret Hospital

Department of Medical Biophysics

The Canadian F.I.G.H.T. (Fluorescence Image-Guided Help in Treating) Breast Cancer Surgical Trial

                                2,922,300

Ralph S. DaCosta

UHN - Princess Margaret Hospital

Department of Medical Biophysics

The FL.I.G.H.T (Fluorescence Image-Guided Healing Trial) for Diabetic Foot Ulcers: A Single Centre Phase II Trial

                                   520,199

James H. Eubanks

UHN - Toronto Western Hospital

Department of Surgery

Altered Microtubule Regulation: A Novel Mechanism Underlying Rett Syndrome Pathogenesis?

                                   390,150

Housheng H. He

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Decode the noncoding in Prostate Cancer

                                   841,500

Housheng H. He

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Function of circular RNA in prostate cancer development and progression

                                   573,750

Mohit Kapoor

UHN - Toronto Western Hospital

Department of Surgery

ULK1 (most upstream autophagy inducer) as a potential therapeutic target in Osteoarthritis

                                   393,976

Gary F. Lewis

UHN - Toronto General Hospital

Department of Medicine

Novel Aspects of the regulation of intestinal lipoprotein particle secretion in humans

                                1,101,600

Fei-Fei Liu

UHN - Princess Margaret Hospital

Department of Radiation Oncology

Seeking Molecular Signatures for Nasopharyngeal Carcinoma

                                1,147,500

Mathieu Lupien

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Delineating the role of noncoding mutations in prostate cancer

                                   956,250

Kristin E. Musselman

UHN - Toronto Rehabilitation Institute

Department of Physical Therapy

Exploring the causes and consequences of falls across the continuum of care in Canadians with spinal cord injury

                                   195,075

Kumaraswamy Nanthakumar

UHN - Toronto General Hospital

Department of Medicine

Augmented Renal Denervation for the Prevention of Cardiac Arrhythmias

                                   600,524

York P. Pei

UHN - Toronto General Hospital

Department of Medicine

Disease-Related Complications and Health Care Utilization in ADPKD

                                   832,320

Trevor J. Pugh

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Non-invasive monitoring of liver cancer recurrence following surgery using circulating tumour DNA sequencing

                                1,331,100

Clinton S. Robbins

UHN - Toronto General Hospital

Department of Laboratory Medicine & Pathobiology

Determining the Role of Macrophage Heterogeneity in Abdominal Aortic Aneurysm Formation

                                   833,850

Aaron David Schimmer

UHN - Princess Margaret Hospital

Department of Medicine

Targeting mitochondrial protein folding in the inter-membrane space as a novel therapeutic strategy for AML

                                   726,750

Sanjeev Sockalingam

UHN - Toronto General Hospital

Department of Psychiatry

Telephone-Based Cognitive Behavioural Therapy for Post-Operative Bariatric Surgery Patients: A Randomized Controlled Trial

                                   489,600

Murray B. Urowitz

UHN - Toronto Western Hospital

Department of Medicine

Defining Phenotypes in Systemic Lupus Erythematosus: towards an individualized approach

                                   609,992

Camilla Zimmermann

UHN - Princess Margaret Hospital

Department of Medicine

Symptom screening and early palliative care in patients with advanced cancer: a randomized trial

                                1,002,150

Richard P. Bazinet

Campus

Department of Nutritional Sciences

Targeting brain inflammation and its resolution. Omega-3 fatty acids, omega-6 fatty acids or both?

                                   691,180

Steffen-Sebastian Bolz

Campus

Department of Physiology

Specifically targeting CFTR activity as a therapeutic strategy to normalize cerebral blood flow in heart failure

                                   466,651

Patricia L. Brubaker

Campus

Department of Physiology

Mechanisms underlying circadian secretion of the anti-diabetic hormone, glucagon-like peptide-1: therapeutic potential

                                   765,000

Leah E. Cowen

Campus

Department of Molecular Genetics

Regulation of Fungal Drug Resistance and Morphogenesis by Hsf1

                                   757,350

Alan R. Davidson

Campus

Department of Molecular Genetics

Developing phage tail-derived nanomachines as strain specific antibacterial agents

                                   944,775

Zhong-Ping Feng

Campus

Department of Physiology

Mechanisms underlying novel pro-survival peptides in neuroprotection

                                   765,000

Lori D. Frappier

Campus

Department of Molecular Genetics

Using Herpesvirus Proteomics to Identify Mechanisms of Cellular Regulation

                                1,201,050

Andrew G. Fraser

Campus

Donnelly Centre

Using C.elegans to learn to predict the personal severity of mutant phenotypes

                                1,246,950

Adria Giacca

Campus

Department of Physiology

Hepatic signalling of glucose and lipid metabolism in vivo

                                   761,175

Stephen E. Girardin

Campus

Department of Laboratory Medicine & Pathobiology

Control of inflammation by a novel cytosolic Unfolded Protein Response (UPR) pathway

                                   902,700

Scott Gray-Owen

Campus

Department of Molecular Genetics

Gonococcal subversion of classical neutrophil functions

                                   898,875

Richard L. Horner

Campus

Department of Medicine

Control of Breathing during Sleep: Brainstem Mechanisms of Respiratory Control

                                   948,600

Philip M. Kim

Campus

Donnelly Centre

A systematic strategy to develop inhibitors of protein-protein interactions as potential therapeutics

                                   650,250

Mary R. L’Abbe

Campus

Department of Nutritional Sciences

The IMPACT of food environment policies on the Canadian food supply, dietary intakes and health: evidence to inform policy action

                                   612,000

Jeffrey E. Lee

Campus

Department of Laboratory Medicine & Pathobiology

Characterizing the mechanism of sperm-egg membrane fusion mediated by Izumo1, Juno, and CD9

                                1,055,700

Alberto Martin

Campus

Department of Immunology

Ubiquitination of histone H2B in B cell immunobiology and cancer

                                   967,725

Karen L. Maxwell

Campus

Department of Biochemistry

Protein inhibitors of CRISPR-Cas9 mediated genome editing: discovery, characterization and development for novel biotechnological applications

                                   824,670

Stephanie A. Nixon

Campus

Department of Physical Therapy

The Sepo III Study: Advancing Chronic Disease Models of Care for People Living with HIV in Resource-Poor Settings

                                   183,600

Stephanie A. Nixon

Campus

Department of Physical Therapy

Toward a Paradigm Shift in Rehabilitation for Adults and Children Living with HIV in Sub-Saharan Africa: Development, Implementation, and Evaluation of a Novel KT Intervention

                                   233,324

Mario A. Ostrowski

Campus

Department of Immunology

The metabolic basis of T cell exhaustion in HIV infection: discovery of novel treatment targets

                                   673,200

Peter J. Roy

Campus

Department of Molecular Genetics

Understanding the Plasma Membrane as a Barrier to Drug Accumulation and Nutrient Absorption

                                   765,000

Nancy Salbach

Campus

Department of Physical Therapy

Getting Older adults OUTdoors (GO-OUT): A randomized controlled trial of a community-based outdoor walking program

                                   569,925

Mikko Taipale

Campus

Donnelly Centre

Systematic phenotyping of Mendelian disease variants

                                1,067,175

Valerie S. Tarasuk

Campus

Department of Nutritional Sciences

Maternal and infant health in association with household food insecurity

                                   504,900

Rachel F. Tyndale

Campus

Department of Pharmacology & Toxicology

Variation in nicotine metabolism in nine clinical trials: a genomics approach to personalizing smoking cessation

                                   753,524

An-Wen Chan

Women's College Hospital

Department of Medicine

Nicotinamide chemoprevention for keratinocyte carcinoma in solid organ transplant recipients: A randomized, placebo-controlled, internal pilot trial

                                   275,400

Lorraine Lipscombe

Women's College Hospital

Department of Medicine

Avoiding diabetes after pregnancy trial in moms (ADAPT-M)

                                   791,776

Paula A. Rochon

Women's College Hospital

Department of Medicine

A Multi-Method Approach to Exploring Prescribing Cascades

                                   488,069

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