CIHR Open Operating Grant Competition – Spring 2014

CIHR Open Operating Grant Competition – Spring 2014

Stephen Strother

Baycrest Centre

Department of Medical Biophysics

Optimising fMRI Detection of Longitudinal Changes in Age-Related Brain Disorders

           586,324

Paul J. Fletcher

Centre for Addiction and Mental Health

Department of Psychiatry

The role of serotonin in addiction-related behaviours

           568,225

Jeffrey H. Meyer

Centre for Addiction and Mental Health

Department of Psychiatry

Neuroinflammation in Major Depressive Disorder and Treatment Resistance

           417,066

Antonio Strafella

Centre for Addiction and Mental Health

Department of Medicine

Cognitive complications in Parkinson's disease: the contribution of dopamine

           747,435

Barbara E. Gibson

Holland Bloorview Kids Rehabilitation Hospital

Department of Physical Therapy

Moving together: Choreographic mappings of children with diverse dis/abilities and their neurological responses to a dance-play event

           180,000

Virginia F. Wright

Holland Bloorview Kids Rehabilitation Hospital

Department of Physical Therapy

Evaluation of the effectiveness of robotic gait training and gait-focused physical therapy programs for children and youth with cerebral palsy: A mixed methods RCT

           873,105

Gabrielle L. Boulianne

Hospital for Sick Children

Department of Molecular Genetics

Drosophila Models of Human Obesity

           751,714

John H. Brumell

Hospital for Sick Children

Department of Molecular Genetics

Mechanisms of cell-to-cell spread by Listeria monocytogenes

           854,480

Brent Derry

Hospital for Sick Children

Department of Molecular Genetics

Molecular control of germline apoptosis in C. elegans

           773,708

James Dowling

Hospital for Sick Children

Department of Paediatrics

Regulators of PI3P metabolism in skeletal muscle development and as modifiers of myotubular myopathy

           462,075

Sean E. Egan

Hospital for Sick Children

Department of Molecular Genetics

Defining the function of Gata3 and TRPS1, A GATA-like protein, in BC

           742,832

Anne Marie Guerguerian

Hospital for Sick Children

Department of Paediatrics

Quantifying brain injury on computed tomography in hospitalized children: a prospective trial

           617,192

Robert V. Harrison

Hospital for Sick Children

Otolaryngology - Head & Neck Surgery

The changing balance of neural inhibition vs. excitation during auditory system development

           595,773

Sevan Hopyan

Hospital for Sick Children

Department of Surgery

Genetic control of mammalian limb pattern

           820,632

Annie Huang

Hospital for Sick Children

Department of Paediatrics

Delineating transforming pathways in childhood primitive neuro-ectodermal brain tumours

           990,596

Chi-Chung Hui

Hospital for Sick Children

Department of Molecular Genetics

Irx3 and Irx5 as novel genetic factors controlling energy homeostasis

           776,814

Edgar T. Jaeggi

Hospital for Sick Children

Department of Paediatrics

Fetal Atrial Flutter & Supraventricular Tachycardia (FAST) Therapy Trial: Proposal of an International Registry and Randomized Controlled Trial (RCT)

       1,349,755

Steven P. Miller

Hospital for Sick Children

Department of Paediatrics

Analgesia and Sedation in the Preterm Neonate: Brain Development and Outcome

       1,104,217

Rulan S. Parekh

Hospital for Sick Children

Department of Paediatrics

Long-Term Survival in Childhood Solid Organ Transplants

           514,679

Lisa A. Robinson

Hospital for Sick Children

Department of Paediatrics

Preventing Chronic Kidney Disease After Acute Kidney Injury

           709,455

John L. Rubinstein

Hospital for Sick Children

Department of Biochemistry

Electron cryomicroscopy of rotary ATPases

       1,062,810

Uri Tabori

Hospital for Sick Children

Department of Paediatrics

Novel implications of THOR hypermethylation in telomere maintenance and gliomageneis

           911,430

James W. Dennis

Mount Sinai Hospital

Department of Molecular Genetics

Metabolic reprogramming in cancer cells and the hexosamine biosynthesis pathway

           664,934

Daniel J. Drucker

Mount Sinai Hospital

Department of Medicine

Glucagon receptor and the control of metabolism

           749,366

John C. Kingdom

Mount Sinai Hospital

Department of Obstetrics & Gynecology

Villous Trophoblast Turnover

           719,234

Robin S. McLeod

Mount Sinai Hospital

Department of Surgery

Development of a Decision Rule for Discharging Patients following Colorectal Surgery based on Post-operative Serum C Reactive Protein and/or Procalcitonin Levels

           358,402

Helen McNeill

Mount Sinai Hospital

Department of Molecular Genetics

Analysis of Fat4 function in mesenchymal-epithelial transitions and kidney development

           821,394

Ravi R. Retnakaran

Mount Sinai Hospital

Department of Medicine

Exenatide and Insulin Glargine Combination Therapy for the Preservation of Pancreatic Beta-cell Function in Early Type 2 Diabetes: A Randomized Controlled Trial

           366,920

Jane Andrea J. Batt

St. Michael's Hospital

Department of Medicine

Mechanisms of Impaired Skeletal Muscle Growth in Intensive Care Unit Acquired Weakness (ICUAW)

           419,206

Karen E. Burns

St. Michael's Hospital

Department of Medicine

Frequency of Screening and SBT Technique Trial: The FAST Trial

           156,771

Philip W. Connelly

St. Michael's Hospital

Department of Medicine

Investigating the role of red blood cells in oxidative stress and thrombogenesis - from 4-hydroxynonenal chemistry to mouse to man

           451,101

Howard M. Leong-Poi

St. Michael's Hospital

Department of Medicine

Next Generation Ultrasound-Mediated Gene Delivery: Targeting Acute Myocardial Infarction-Reperfusion

           654,709

Ron Wald

St. Michael's Hospital

Department of Medicine

Two phosphAte taRGets in End-stage renal disease Trial (TARGET): Intensive vs liberalized phosphate control in hemodialysis recipients

           168,394

Isabelle Aubert

Sunnybrook Health Sciences Centre

Department of Laboratory Medicine & Pathobiology

Brain degeneration and regeneration in preclinical models of Alzheimer's disease

           981,308

F. Stuart Foster

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

Development of biogenic gas nanostructures as a new class of molecular reporters for ultrasound

           731,378

Benjamin I. Goldstein

Sunnybrook Health Sciences Centre

Department of Psychiatry

Neural and Peripheral Approaches Linking Circuitry and Circulation in Adolescent Bipolar Disorder

           692,124

Mario Masellis

Sunnybrook Health Sciences Centre

Department of Medicine

Genetic Frontotemporal Dementia Initiative (GENFI) in Canada

           932,818

Richard Swartz

Sunnybrook Health Sciences Centre

Department of Medicine

DOC-Utility: Simple screening of Depression, Obstructive sleep apnea and Cognitive impairment to Identify Stroke Clinic Patients at Risk of Adverse Outcomes

           725,535

Hannah Wunsch

Sunnybrook Health Sciences Centre

Department of Anesthesia

Identifying Risk Factors for and Outcomes following Rehospitalizations for Elderly Critically Ill Patients

           189,225

Robert Chen

UHN - Toronto Western Hospital

Department of Medicine

Pathophysiology of Parkinson's disease

           915,575

David Z. Cherney

UHN - Toronto General Hospital

Department of Medicine

Blockade of acE and Treatment With Empagliflozin - Effects on hyperfiltratioN in Type 1 Diabetes: The BETWEEN-T1D Study

           731,520

Jonathan Downar

UHN - Toronto Western Hospital

Department of Psychiatry

Identifying fMRI and clinical predictors of treatment outcome for conventional and theta-burst repetitive transcranial magnetic stimulation in major depressive disorder

           606,651

Shannon E. Dunn

UHN - Toronto General Hospital

Department of Immunology

Obesity and Autoimmune Risk

           703,340

Michael G. Fehlings

UHN - Toronto Western Hospital

Department of Surgery

Mechanistic insights and neuroprotective approaches to enhance recovery in age related spinal cord degeneration

           569,330

Mansoor Husain

UHN - Toronto General Hospital

Department of Medicine

Role of c-Myb in vascular smooth muscle cell biology and blood pressure regulation

           794,335

Kevin C. Kain

UHN - Toronto General Hospital

Department of Medicine

PPAR-gamma agonists as novel interventions for severe malaria

           607,830

Mathieu Lupien

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Investigating the role of EZH2 genomic localization in the response to EZH2 inhibition in breast cancer subtypes

           719,010

Ian D. McGilvray

UHN - Toronto General Hospital

DEPT OF SURGERY

Nanoparticle targeting of the liver

           483,813

Benjamin G. Neel

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Cell of Origin and Tumor Initiating Cells in Serous Ovarian Cancer

           804,047

Aaron David Schimmer

UHN - Princess Margaret Hospital

Department of Medicine

Targeting the mitochondrial proteasome, ClpP, in AML

           707,495

Nazia Selzner

UHN - Toronto General Hospital

Department of Medicine

THE ROLE OF THE NOVEL FGL2-FcgammaRII/RIII PATHWAY IN CHRONIC VIRAL HEPATITIS

           302,126

Vuk Stambolic

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Nuclear PTEN function in tumor suppression

           626,592

Maria Carmela Tartaglia

UHN - Toronto Western Hospital

Department of Medicine

Multimodal Assessment For Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration

           572,884

Ming-Sound Tsao

UHN - Princess Margaret Hospital

Department of Laboratory Medicine & Pathobiology

Functional Genomics and in vitro Modeling of Human Pancreatic Carcinogenesis

           754,235

David R. Urbach

UHN - Toronto General Hospital

Department of Surgery

The Inference From Observational Research Methods (INFORM) Project

           501,723

Richard P. Bazinet

Campus

Department of Nutritional Sciences

Novel docosahexaenoic acid derived mediators in the resolution of neuroinflammation

           384,468

Benjamin J. Blencowe

Campus

Donnelly Centre

Global analysis of alternative splice variant function in development and disease

       1,907,784

Steffen-Sebastian Bolz

Campus

Department of Physiology

Constitutive Smooth Muscle Tumor Necrosis Factor Regulates Microvascular Myogenic Responsiveness and Systemic Blood Pressure

           263,673

Grant W. Brown

Campus

Department of Biochemistry

The role of mRNA processing bodies in genome stability

           823,600

Aled M. Edwards

Campus

Donnelly  Centre

Investigation of phage-encoded bacterial fitness factors and analysis of their effects on bacterial pathogenesis and human disease

           852,241

Cordula Enenkel

Campus

Department of Biochemistry

Dynamic Organization of Proteasomes Droplets in Quiescence in Yeast

           717,360

Mary R. L’Abbe

Campus

Department of Nutritional Sciences

PAUSE - Prevalence and consumer attitudes, understanding, and use of supplemented foods to inform education in Canada

           349,703

Jeremy Mogridge

Campus

Department of Laboratory Medicine & Pathobiology

Assembly of the Anthrax Toxin Protein Translocase

           658,800

Michael Ohh

Campus

Department of Laboratory Medicine & Pathobiology

Molecular characterization of EpoR regulation in cancer progression

           834,840

A;exander F. Palazzo

Campus

Department of Biochemistry

The role of RanBP2 and sumoylation in regulating the translation of secretory mRNAs

           818,084

Amy J. Ramsey

Campus

Department of Pharmacology & Toxicology

Plasticity of neural circuits relevant to schizophrenia

           428,291

Janice Robertson

Campus

Tanz CRND

The TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis

           959,057

Sachdev S. Sidhu

Campus

Donnelly Centre

Design and Application of Combinatorial Libraries of Synthetic Antibodies and Alternative Scaffolds

           914,636

Sachdev S. Sidhu

Campus

Donnelly Centre

Specific inhibitors of ubiquitin ligases and deubiquitinases

           919,406

Joel C. Watts

Campus

Tanz CRND

Self-propagating protein aggregates in Alzheimer's disease

           745,041

Fiona Webster

Campus

Department of Family and Community Medicine

Finding the complex patient in patient-centred care: an institutional ethnography of chronic pain management in family medicine

           238,578

Michael B. Wheeler

Campus

Department of Physiology

Mechanisms linking beta cell dysfunction to type 2 diabetes

       1,025,435

An-Wen Chan

Women's College Hospital

Department of Medicine

Screening for non-melanoma skin cancer after solid organ transplantation

           161,485

 

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